A case report: Surgery and Metronomic Chemotherapy with Cyclophosphamide and Piroxicam of High-grade Soft Tissue Sarcoma in A 5-year-old Dog รายงานสัตว์ป่วย: การรักษาทางศัลยกรรมร่วมกับเมโทรโนมิก คีโมเทอราปี ด้วยไซโคลฟอสฟาไมด์ และไพรอกซิแคมในสุนัข อายุ 5 ปีที่ป่วยด้วยมะเร็งร้ายแรงซอฟท์ทิชชูซาร์โคมา

Abstract

          A 5-year-old, female, neutered mixed breed dog was referred for the treatment of a large high-grade sarcoma mass of the left trunk. This dog with clinical stage T₄N₀M₀ (stage IIB) was treated with surgery and metronomic therapy with 2-drug combination consisting of orally administered low-dose cyclophosphamide at 10 mg/m² and full-dose piroxicam at 0.3 mg/kg daily coupled with surgery.  The dog was re-evaluated at 3-month intervals throughout her treatment period.  Thus far, this dog is alive with pleasing on her quality of life.  Recurrence or metastases has not been found and disease free interval is more than 24 months. This case report suggested that the 2-drug regimen was very effective in inhibiting the regrowth of tumor in this dog with high grade soft tissue sarcoma.