Efficacy of certain intrauterine immunomodulators in management of endometritis in postpartum graded Murrah buffaloes

Main Article Content

Derangula Venkatesh Kudikilla Venkataramana Lakavath Ramsingh Bommu Swathi


The present study is conducted to evaluate the efficacy of certain immunomodulators on recovery and conception rate in post partum endometritic buffaloes. Total 50 buffaloes were selected for the study and randomly divided into five groups. The buffaloes of Group 1 were given with a single dose of 100 μg E. coli lipopolysaccharide as intrauterine, Group 2 buffaloes were treated with a single dose of 2 mg Lysozyme, Group 3 was treated with 4 g of Cephalexin for three consecutive days. While, Group 4 buffaloes were treated with a single dose of 2 mg Lysozyme + 4 g of Cephalexin and Group 5 was treated with 30 ml of normal saline and was kept as control. All therapeutics were infused into the uterus after dissolving in sterile water. The efficacy of treatment was assessed by declines in bacterial load and PMNL cell count after treatment. The overall conception rate was 88.88, 71.42, 66.66, 75.00 and 33.33% in Group 1, 2, 3, 4 and Group 5, respectively. 


Download data is not yet available.

Article Details

How to Cite
VENKATESH, Derangula et al. Efficacy of certain intrauterine immunomodulators in management of endometritis in postpartum graded Murrah buffaloes. Buffalo Bulletin, [S.l.], v. 41, n. 1, p. 171-175, mar. 2022. ISSN 2539-5696. Available at: <https://kuojs.lib.ku.ac.th/index.php/BufBu/article/view/3081>. Date accessed: 27 may 2022.
Original Article


Anderson, K.L., N.A. Hemeida, A. Frank, H.L. Whitmore and B.K. Gustafsson. 1985. Collection and phagocytic evaluation of uterine neutrophilic leukocytes. Theriogenology, 24(3): 305-317. DOI: 10.1016/0093-691x(85)90221-3

Denis-Robichaud, J. and J. Dubuc. 2015. Determination of optimal diagnostic criteria for purulent vaginal discharge and cytological endometritis in dairy cows. J. Dairy Sci., 98(10): 6848-6855. DOI: 10.3168/jds.2014-9120

Deori, S. 2002. Use of bacterial modulins in treatment of endometritis cows, M.V.Sc. Thesis, Indian Veterinary Research Institute, Uttar Pradesh, India.

Diliello, L.R. 1979. Antimicrobial chemical agents. Clinical Microbiology, Connecticut: AVI Publishing Company, Westport, USA. p. 120-125.

Galvao, K.N. and J.E.P. Santos. 2014. Recent advances in the immunology and uterine microbiology of healthy cows and cows that develop uterine disease. Turk. J. Vet. Anim. Sci., 38(6): 577-588. DOI: 10.3906/vet-1407-29

Hussain, A.M. 1989. Bovine uterine defense mechanisms: A review. Zentralblatt fur Veterinarmedizin Reihe B., 36(9): 641-651. DOI: 10.1111/j.1439-0450.1989.tb00657.x

Methai, A. and Rajasundram. 2002. Efficacy of Lipopolysaccharide and plasma in the treatment of endometritis in cows. In Proceeding 18th Annual Convention and National Symposium of Indian Society for Study of Animal Reproduction, Indian Veterinary Research Institute, Izatnagar, India.

Noakes, D.E., T.J. Parkinson, G.C.W. England and G.H. Arthur. 2001. Arthurs Veterinary Reproduction and Obstetrics, 8th ed. W.B. Suanders, Philadelphia, Pennsylvania, USA. 333p.

Pateria, A.K. and C.V.S. Rawal. 1990. White side test for subclinical metritis in buffaloes. Indian J. Anim. Reprod., 11: 142.