The milk IGF-2 level is positively correlated with milk yield in Anatolian water buffaloes


  • Hakan Guler Department of Animal Health Economics and Management, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, Turkey
  • Gul Fatma Yarim Department of Biochemistry, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, Turkey
  • Murat Yarim Department of Pathology, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, Turkey
  • Ozkan Duru Department of Biochemistry, Faculty of Veterinary Medicine, Kirikkale University, Kirikkale, Turkey
  • Ayris Gokceoglu Department of Biochemistry, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, Turkey



Bubabus bubalis, buffaloes, Anatolian water buffalo, insulin-like growth factor-2, milk yield


The aim of this study was to investigate the relationship between milk insulin-like growth factor-2 (IGF-2) concentration and milk yield in Anatolian water buffaloes. This study was conducted on milk samples from 80 Anatolian water buffaloes. Milk samples collected from buffaloes were evaluated for subclinical mastitis. For this purpose, the California mastitis test and somatic cell count were performed in milk samples taken from four different mammary lobes of buffaloes. The milk IGF-2 level was determined by an enzyme-linked immunosorbent assay kit. Milk IGF-2 concentration ranged from 21.6 ng/ml - 63.2 ng/ml in Anatolian water buffaloes. The IGF-2 concentration in Anatolian water buffaloes milk was 40.1±8.5 ng/ml. Milk IGF-2 was positively correlated with milk yield (r2=0.941, P<0.01). Our results showed that milk IGF-2 concentration was associated with milk yield in Anatolian buffaloes. These findings show that locally synthesized IGF-2 can affect milk yield. This study contributes to the understanding of the composition of buffalo milk, which has an important value in human nutrition. It is recommended to confirm the results of similar measurements in milk from other animal species used for human consumption.


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How to Cite

Guler, H., Yarim, G. F., Yarim, M., Duru, O., & Gokceoglu, A. (2023). The milk IGF-2 level is positively correlated with milk yield in Anatolian water buffaloes. Buffalo Bulletin, 42(2), 213–222.



Original Article