Myostatin gene polymorphisms do not determine muscle hypertrophy in buffaloes: A case report

Authors

  • Jackeline Santos Alves Escola de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia (UFBA), Bahia, Brazil
  • Sebastião Tavares Rolim-Filho Instituto da Saúde e Produção Animal, Universidade Federal Rural da Amazônia (UFRA), Belém-Pará, Brazil
  • Humberto Tonhati Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista (Unesp), São Paulo, Brazil
  • Raphael Bermal Costa Escola de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia (UFBA), Bahia, Brazil
  • Gregório Miguel Ferreira de Camargo Escola de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia (UFBA), Bahia, Brazil

DOI:

https://doi.org/10.56825/bufbu.2024.4335474

Keywords:

Bubalus bubalis, buffaloes, double musculature, GDF8, MSTN, Murrah

Abstract

The aim of the study was to detect variations in the exonic and intronic regions of the myostatin gene in buffaloes with different body conformations. The regions of the gene were analyzed using the PCR-sequencing technique comparing an animal with muscle hypertrophy and ten animals with normal musculature. The hypertrophied buffalo sequence was compared to the others and no exclusive genotype was identified. It suggests that the found MSTN variants are not singly associated to muscle hypertrophy in buffaloes.

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References

ABCB. 2023. Búfalo. Associação Brasileira de Criadores de Búfalos, São Paulo, Brazil.Available on: https://bufalo.com.br/obufalo

Aiello, D., K. Patel and E. Lasagna. 2018. The myostatin gene: an overview of mechanisms of action and its relevance to livestock animals. Anim. Genet., 49(6): 505-519. DOI: 10.1111/age.12696

Da Silva, J.A.R., A.R. Garcia, A.M. de Almeida, A.S. Bezerra and J. de B.L. Junior. 2021. Water buffalo production in the Brazilian Amazon Basin: A review. Trop. Anim. Health Pro., 53(343): 1-21. DOI: 10.1007/s11250-021-02744-w

Jakaria, J., W.L.N. Aliyya, R. Ismail, S.Y. Siswanti, M.F. Ulum and R. Priyanto. 2021. Discovery of SNPs and indel 11-bp of the myostatin gene and its association with the double-muscled phenotype in Belgian blue crossbred cattle. Gene, 784(5). DOI: 10.1016/j.gene.2021.145598

McPherron, A.C., A.M. Lawler and S.J. Lee. 1997. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature, 387(6628): 83-90. DOI: 10.1038/387083a0

Páez, M.A.R., N.J.R. Tovar, G. Mendoza-Sánchez, M.F. Muñoz, B.J.S. Molina, A.F.S. Torres, J.A.B. Gutíerrez and J.D.R. Buitrago. 2021. Sequencing and analysis of the myostatin gene (GDF-8) in Bubalus bubalis young animals to determine the existence of possible mutations expressed in double musculature phenotype. Journal of Buffalo Science, 10: 1-5. DOI: 10.6000/1927-520X.2021.10.01

Tantia, M.S., R.K. Vijh, B. Mishra and S.T.B. Kumar. 2007. Sequence of GDF 8 (Myostatin) gene in Bubalus bubalis. Anim. Biotechnol., 18(3): 177-181. DOI: 10.1080/10495390601115526

Buffalo with muscle hypertrophy.

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Published

2024-09-30

How to Cite

Santos Alves, J., Tavares Rolim-Filho, S., Tonhati, H., Bermal Costa, R., & de Camargo, G. M. F. (2024). Myostatin gene polymorphisms do not determine muscle hypertrophy in buffaloes: A case report. Buffalo Bulletin, 43(3), 377–380. https://doi.org/10.56825/bufbu.2024.4335474

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Section

Short Communication

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