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Peromelia is a rare congenital malformation with variable degrees of limb reduction defects involving the loss of distal structures. Reports of peromelia in buffalo calves are meagre and tetra- peromelia are the rarest. The present case is a report of female graded murrah calf that has all four limbs incompletely formed. Both the fore limbs were formed up to shoulder region only. The scapulae were well formed except glenoid cavity and rest of the limb was absent. Humerus was represented as a small tubercle attached to glenoid. Both the hind limbs were formed up to distal one third of femur and rest of the limb was completely absent. To the author's knowledge, this is the first report of tetra- peromelia in a graded murrah buffalo from India.