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The theme of investigation was the herd of 1230 Murrah breed buffaloes at the dairy farm of Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana. The study was conducted for the episode of forty years 1971 to 2010, to make out the mortality pattern at this organized herd. The reasons for mortality were the affections of Digestive and Respiratory systems, also circulatory disturbances and the Unclassified reasons. The share of mortality of buffaloes with circulatory disturbances was principal i.e. 44.55%, followed by affections of digestive system 26.61%, unclassified condition were on the tune of 17.95% and the least was accounted at the affections of respiratory system with only 10.89%. The seasonal effect, period and parity have not any concern on the mortality pattern of animal and also it was nonsignificant too.