Antioxidant/oxidant status, metabolic profile status and concentration of some inflammatory cytokines in Egyptian buffalo-cows suffered from ovarian inactivity
Keywords:
Bubalus bubalis, buffaloes, inactive ovaries, heat stress, oxidative stress, inflammatory indicatorsAbstract
Anestrous condition due to inactive ovaries is a major problem in buffalo-cows especially in summer season, which may decrease the profitability due to prolonged calving interval. The aim of the study was to evaluate the serum concentration of some oxidative biomarkers, metabolic and inflammatory indicators in Egyptian buffalo-cows suffered from inactive ovaries during summer season. Thirty pluriparous Egyptian buffalo-cows were included in the current study, fifteen cows were cyclic and the remaining 15 were, suffering from inactive ovaries. Blood samples were collected from both of the experimental groups for measurement of serum total anti-oxidant capacity (TAC), advanced oxidized protein products (AOPP), non-esterified fatty acid (NEFA), leptin hormone, inflammatory cytokines; tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and interleukin-1 beta (IL-1β) and inflammatory proteins (C-reactive protein and ceruplasmin). In comparison to normal cyclic buffalo-cows, buffalo cows suffered from ovarian inactivity showed higher concentration of AOOP, TNF-α, IL-1ß, IL-6, C- reactive protein, ceruplasmin and NEFA, but it showed lower concentration of TAC and leptin. The antioxidant/oxidant status and informatory cytokines may be implicated fundamentally in the development of ovarian inactivity.
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References
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Rivest, S. and C. Rivier. 1993. Central mechanisms and sites of action involved in the inhibitory effects of CRF and cytokines on LHRH neuronal activity. Ann. NY. Acad. Sci., 697: 117-141. DOI: 10.1111/j.1749-6632.1993.tb49928.x
Sheldon, I.M., S.B. Price, J. Cronin, R.O. Gilbert and J.E. Gadsby. 2009. Mechanisms of infertility associated with clinical and subclinical endometritis in high producing dairy cattle. Reprod. Domest. Anim., 44(Suppl. 3): 1-9. DOI: 10.1111/j.1439-0531.2009.01465.x
Singh, J., A.S. Nanda and G.P. Adams. 2000. The reproductive pattern and efficiency of female buffaloes. Anim. Reprod. Sci., 60-61: 593-604. DOI: 10.1016/s0378-4320(00)00109-3
Singh, B., S.P.S. Ghuman, R.S. Cheema and A.K. Bansal. 2016. Melatonin implant induces estrus and alleviates oxidative stress in summer anestrus buffalo. Indian Journal of Animal Reproduction, 37(2): 28-32
Spicer, L.J. and E. Alpizar. 1994. Effects of cytokines on FSH-induced estradiol production by bovine granulosa cells in vitro: Dependence on size of follicle. Domest. Anim. Endocrin., 11(1): 25-34. DOI: 10.1016/0739-7240(94)90034-5
Sugino, N. 2006. Roles of reactive oxygen species in the corpus luteum. Anim. Sci. J., 77(6): 556-565. DOI: 10.1111/j.1740-0929.2006.00386.x
Talukder, S., L. Ingeenhoff, L.L. Kerrisk and P. Celi. 2014. Plasma oxidative stress biomarkers and progesterone profile s in a dairy cow diagnosed with an ovarian follicular cyst. Vet. Quart., 34(2): 114-117. DOI: 10.1080/01652176.2014.953264
Trevisan, M., R. Browne, M. Ram, P. Muti, J. Freudenheim, A.M. Carosella and D. Armstrong. 2001. Correlates of markers of oxidative status in the general population. Am. J. Epidemiol., 154(4): 348-356. DOI: 10.1093/aje/154.4.348
Vanholder, T., J.L.M.R. Lerory, A. Van Soom, G. Opsomer, D. Maes, M. Coryn and A. de Kruif. 2005. Effect of non-esterified fatty acids on bovine granulosa cells steroidogenesis and proliferation in vitro. Anim. Reprod. Sci., 87(1-2): 33-44. DOI: 10.1016/j.anireprosci.2004.09.006
Wakayo, B.U., P.S. Brar and S. Prabhaker. 2015. Review on mechanism of dairy summer infertility and implications for hormonal intervention. Open Veterinary Journal, 5(1): 6-10. DOI: 10.4314/OVJ.V5I1
Watanobe, H. and Y. Hayakawa. 2003. Hypothalamic interleukin-1 beta and tumor necrosis factor-alpha, but not interleukin-6, mediate the endotoxin-induced suppression of the reproductive axis in rats. Endocrinology, 144(11): 4868-4875. DOI: 10.1210/en.2003-0644
Williams, C.A., D.S. Kronfeld, T.M. Hess, K.E. Saker, J.N. Waldron, K.M. Crandell, R.M. Hoffman and P.A. Harris. 2002. Antioxidant supplementation and subsequent oxidative stress of horses during an 80-km endurance race. J. Anim. Sci., 82(2): 588-594. DOI: 10.2527/2004.822588x
Witko-Sarsat, V., M. Frienlander, T.N. Khao, C. Capeillere-Blandin, A.T. Nguyen, S. Canteloup, J.M. Dayer, B. Junger, T. Drueke and B. Descampus-Latscha. 1998. Advanced oxidation protein products as a novel mediator of inflammation and monocytes activation in chronic renal failure 1, 2. J. Immunol., 161(5): 2524-2532.
Yoo, M.J., M. Nishihara and M. Takahashi. 1997. Tumor necrosis factor alpha mediates endotoxin induced suppression of gonadotropin releasing hormone pulse generator activity in the rat. Endocr. J., 44(1): 141-148. DOI: 10.1507/endocrj.44.141
Zhang, X., X.H. Li, X. Ma, Z.H. Wang, S. Lu and Y.L. Guo. 2006. Redox-inducedapoptosis of human oocytes in resting follicles in vitro. J. Soc. Gynecol. Invest., 13(6): 451-458. DOI: 10.1016/j.jsgi.2006.05.005
Al-Gubory, K.H., P.A. Fowler and C. Garrel. 2010. The roles of cellular reactive oxygen species, oxidative stress and antioxidant in pregnancy outcomes. Int. J. Biochem. Cell. B., 42: 1634-1650. DOI: 10.1016/j.biocel.2010.06.001
Beam, S.W. and W.R. Butler. 1999. Effects of energy balance on follicular development and first ovulation in postpartum dairy cows. J. Reprod. Fertil., 54: 411-424.
Borghese, A., V. Barile, G. Terzano, G. Annicchiarico, A. Debenedetti and A. Malfatti. 1993. Anoestrus length in Italian buffalo cows. Note I, p. 389-392. In Prospects of Buffalo Production in the Mediterranean and the Middle East: Proceedings of the Joint ESAP, EAAP, FAO, ICAMS and OIE Symposium, 1992, Cairo, Egypt. PUDOC. (EAAP Publication, 62), Wageningen, Netherlands.
Caprio, M., E. Fabbrini, A.M. Isidori, A. Aversa and A. Fabbri. 2001. Leptin in reproduction. Trends Endocrin. Met., 12(2): 65-72. DOI: 10.1016/j.biochi.2012.02.022
Cheeseman, K.H. and T.F. Slater. 1993. An introduction to free radical biochemistry. Brit. Med. Bull., 49(3): 481-493. DOI: 10.1093/oxfordjournals.bmb.a072625
Chou, M.Y., K. Hartvigsen, L.F. Hansen, L. Fogelstrand, P.X. Shaw, A. Boullier, C.J. Binder and J.L. Witztum. 2008. Oxidation-specific epitopes are important targets of innate immunity. J. Intern. Med., 263(5): 479-488. DOI: 10.1111/j.1365-2796.2008.01968.x
Cronstein, B.N. 2007. Interleukin-6: A key mediator of systemic and local symptoms in rheumatoid arthritis. Bulletin of the NYU Hospital for Joint Diseases, 65(1): S11-S15.
Das, G.K. and F.A. Khan. 2010. Summer anoestrus in buffalo- A review. Reprod. Domest. Anim., 45(6): 483-494. DOI: 10.1111/j.1439-0531.2010.01598.x
Gad El-Karim, D.R. and R.S. Ghallab. 2020. Serum biochemical changes in relation to some nutritional and hormonal managements for treatment of inactive ovaries in buffaloes. Alexandria Journal of Veterinary Sciences, 66(2): 78-84. DOI: 10.5455/ajvs.111580
Gupta, S., A. Choi, H.Y. Yu, S.M. Czerniak, E.A. Holick, L.J. Paolella, A. Agarwal and C.M. Combelles. 2011. Fluctuations in total antioxidant capacity, catalase activity and hydrogen peroxide levels of follicular fluid during bovine folliculogenesis. Reprod. Fert. Develop., 23(5): 673-680. DOI: 10.1071/RD10270
Herdt, T.H. 2000. Variability characteristics and test selection in herd level nutritional and metabolic profile testing. Vet. Clin. N. Am.-Food A., 16(2): 387-403. DOI: 10.1016/s0749-0720(15)30111-0
Kalra, P.S., T.G. Edwards, B. Xu, M. Jain and S.P. Kalra. 1998. The anti-gonadotropic effects of cytokines: The role of neuropeptides. Domest. Anim. Endocrin., 15(5): 321-332. DOI: 10.1016/s0739-7240(98)00030-7
Koracevic, D., G. Koracevic, V.S. Djordjevic, S. Andrejevic and V. Cosic. 2001. Method for the measurement of antioxidant activity in human fluids. J. Clin. Pathol., 54(5): 356-361. DOI: 10.1136/jcp.54.5.356
P.R. Kumar, S.K. Singh, S.D. Kharche, G.C. Sharma, B.K. Behera, S.N. Shukla, H. Kumar and S.K. Agarwal. 2014. Anestrus in cattle and buffalo: Indian perspective. Advances in Animal and Veterinary Sciences, 2(3): 124-138. DOI: 10.14737/journal.aavs/2014/2.3.124.138
Maffei, M., J. Halaas, E. Ravussin, R.E. Pratleyy, G.H. Lee, Y. Zhang, H. Fei, S. Kim, R. Lallone, S. Ranganathan and P.A. Kern. 1995. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat. Med., 1(11): 1155-1161. DOI: 10.1038/nm1195-1155
Rivest, S. and C. Rivier. 1993. Central mechanisms and sites of action involved in the inhibitory effects of CRF and cytokines on LHRH neuronal activity. Ann. NY. Acad. Sci., 697: 117-141. DOI: 10.1111/j.1749-6632.1993.tb49928.x
Sheldon, I.M., S.B. Price, J. Cronin, R.O. Gilbert and J.E. Gadsby. 2009. Mechanisms of infertility associated with clinical and subclinical endometritis in high producing dairy cattle. Reprod. Domest. Anim., 44(Suppl. 3): 1-9. DOI: 10.1111/j.1439-0531.2009.01465.x
Singh, J., A.S. Nanda and G.P. Adams. 2000. The reproductive pattern and efficiency of female buffaloes. Anim. Reprod. Sci., 60-61: 593-604. DOI: 10.1016/s0378-4320(00)00109-3
Singh, B., S.P.S. Ghuman, R.S. Cheema and A.K. Bansal. 2016. Melatonin implant induces estrus and alleviates oxidative stress in summer anestrus buffalo. Indian Journal of Animal Reproduction, 37(2): 28-32
Spicer, L.J. and E. Alpizar. 1994. Effects of cytokines on FSH-induced estradiol production by bovine granulosa cells in vitro: Dependence on size of follicle. Domest. Anim. Endocrin., 11(1): 25-34. DOI: 10.1016/0739-7240(94)90034-5
Sugino, N. 2006. Roles of reactive oxygen species in the corpus luteum. Anim. Sci. J., 77(6): 556-565. DOI: 10.1111/j.1740-0929.2006.00386.x
Talukder, S., L. Ingeenhoff, L.L. Kerrisk and P. Celi. 2014. Plasma oxidative stress biomarkers and progesterone profile s in a dairy cow diagnosed with an ovarian follicular cyst. Vet. Quart., 34(2): 114-117. DOI: 10.1080/01652176.2014.953264
Trevisan, M., R. Browne, M. Ram, P. Muti, J. Freudenheim, A.M. Carosella and D. Armstrong. 2001. Correlates of markers of oxidative status in the general population. Am. J. Epidemiol., 154(4): 348-356. DOI: 10.1093/aje/154.4.348
Vanholder, T., J.L.M.R. Lerory, A. Van Soom, G. Opsomer, D. Maes, M. Coryn and A. de Kruif. 2005. Effect of non-esterified fatty acids on bovine granulosa cells steroidogenesis and proliferation in vitro. Anim. Reprod. Sci., 87(1-2): 33-44. DOI: 10.1016/j.anireprosci.2004.09.006
Wakayo, B.U., P.S. Brar and S. Prabhaker. 2015. Review on mechanism of dairy summer infertility and implications for hormonal intervention. Open Veterinary Journal, 5(1): 6-10. DOI: 10.4314/OVJ.V5I1
Watanobe, H. and Y. Hayakawa. 2003. Hypothalamic interleukin-1 beta and tumor necrosis factor-alpha, but not interleukin-6, mediate the endotoxin-induced suppression of the reproductive axis in rats. Endocrinology, 144(11): 4868-4875. DOI: 10.1210/en.2003-0644
Williams, C.A., D.S. Kronfeld, T.M. Hess, K.E. Saker, J.N. Waldron, K.M. Crandell, R.M. Hoffman and P.A. Harris. 2002. Antioxidant supplementation and subsequent oxidative stress of horses during an 80-km endurance race. J. Anim. Sci., 82(2): 588-594. DOI: 10.2527/2004.822588x
Witko-Sarsat, V., M. Frienlander, T.N. Khao, C. Capeillere-Blandin, A.T. Nguyen, S. Canteloup, J.M. Dayer, B. Junger, T. Drueke and B. Descampus-Latscha. 1998. Advanced oxidation protein products as a novel mediator of inflammation and monocytes activation in chronic renal failure 1, 2. J. Immunol., 161(5): 2524-2532.
Yoo, M.J., M. Nishihara and M. Takahashi. 1997. Tumor necrosis factor alpha mediates endotoxin induced suppression of gonadotropin releasing hormone pulse generator activity in the rat. Endocr. J., 44(1): 141-148. DOI: 10.1507/endocrj.44.141
Zhang, X., X.H. Li, X. Ma, Z.H. Wang, S. Lu and Y.L. Guo. 2006. Redox-inducedapoptosis of human oocytes in resting follicles in vitro. J. Soc. Gynecol. Invest., 13(6): 451-458. DOI: 10.1016/j.jsgi.2006.05.005
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2021-11-12
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El-Amrawi, G., El-Karim, D. G., & El-Sayed, Y. (2021). Antioxidant/oxidant status, metabolic profile status and concentration of some inflammatory cytokines in Egyptian buffalo-cows suffered from ovarian inactivity. Buffalo Bulletin, 40(4), 39–45. Retrieved from https://kuojs.lib.ku.ac.th/index.php/BufBu/article/view/4678
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