ASSESSMENT OF EFFICACY OF CEFTIZOXIME AND MARBOFLOXACIN PARENTRAL IN TREATMENT OF CLINICAL MASTITIS IN BUFFALOES

Abstract

The study aimed to assess the effectiveness of Ceftizoxime and marbofloxacin antibiotic on bacteriological cure, clinical cure and pathogen cure in lactation clinical mastitic (CM) buffaloes. The research was carried out between September 2021 and March 2022 on 48 lactating buffaloes with clinical mastitis (Treatment group, T1 = 24 and Treatment group T2 = 24). Most of the buffaloes were from farmers' doorstep and some from buffalo herds of Bidar in Karnataka. Follow-ups were done on day 7 and day 14. Buffaloes (24) in different lactation with infected quarters received ceftizoxime treatment on day 0 and repeated after day 3. while treatment (T2) buffaloes (24) in different lactation with infected quarters received marbofloxacin treatment on day 0 and repeated after day 3. All the animals received supportive therapy for five days. In Treatment group 1 (T1), 91.66 % (22/24) of milk samples tested positive in culture on day 0, while 29.16% (7/24) and 20.83% (5/24) of culture-positive samples were found on day 7 and day 14 after treatment. In Treatment group 2 (T2), 95.83% (23/24) of milk samples tested positive in culture on day 0, while 20.83% (5/24) and 8.33% (2/24) of culture-positive samples were found on day 7 and day 14 after treatment.

The most common causative agent was Staphylococcus aureus, Escherichia coli, Streptococcus spp., Pseudomonas and mixed infection. Although the bacterial cure rate for IMI was 70.84% at day 7 after treatment in Treatment group 1, it increased to 79.17% at day 14 in the same group. A bacteriological cure rate of 87.50% was observed 7 days after treatment in Treatment group 2, while a rate of 91.66% was observed 14 days post-treatment. The Treatment group T2 exhibited slightly superior clinical and pathogen cure rates to the Treatment group T1.