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Twenty four postpartum anoestrus buffaloes were subjected to treatment with Ovsynch, Heatsynch and CIDR plus Heatsynch. Therapeutic efficacy of different hormonal protocols in terms of oestrus induction efficiency was found to be 66.66, 83.33 and 100% with a mean post treatment oestrus induction intervals of 19.50±0.53, 15.20±0.61 and 17.20±0.91 h, while conception rate was recorded as 75.00, 60.00 and 83.33%, respectively in Ovsynch, Heat synch and CIDR plus Heatsynch groups. The mean plasma progesterone concentration (ng/ml) in group Ovsynch, Heatsynch and CIDR plus Heatsynch on day 0 was increased significantly (P<0.01) to day 7 where as the value was decreased on day 9 and day 10, however no significant (P>0.05) difference was recorded in control group. The highest value was found in CIDR plus Heatsynch group on day 7 (4.48±0.05) and lowest value was recorded on day 10 (0.53±0.01).