Therpeutic efficacy evaluation of commonly used antitrypanosomal drugs in naturally infected buffaloes
Keywords:
Bubalus bubalis, buffaloes, therapeutic efficacy, anti-trypanosomal drugs, percent recovery, trypanosomosisAbstract
In present investigation therapeutic efficacy of three most commonly used anti-trypanosomal drugs (isometamidium chloride hydrochloride, diminazine aceturate, and quinapyramine sulphate) were studied. Evaluations of therapeutic efficacy were assessed done on the basis of percent recovery assessment, hematological and biochemical alteration on day 0, day 7th and day 14th post treatment. All three drugs were found effective against the trypanosomosis in buffalo but the extent of improvement in terms of hematological values, biochemical values and percent recovery was observed maximum in the treatment with isometamidium chloride hydrochloride followed by diminazene aceturate and least with the quinapyramine sulphate.
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References
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Ajayi, O.O., E.L. Toshak, O.B. Obaloto, B. Iliyasu, A.C. Igweh, A.J. Dadah and C.O. Idehen. 2013. Comparative efficacy of Berenil and Samorin in albino rats experimentally infected with current field isolates of T. brucei brucei. International Journal of Biological and Chemical Sciences, 7(4): 1452-1460. DOI: 10.4314/ijbcs.v7i4.3
Akanji, M.A., O.S. Adeyemi, S.O. Oguntoye and F. Sulyman. 2009. Psidium guajava extract reduces trypanosomosis associated lipid peroxidation and raises glutathione concentrations in infected animals. EXCLI J., 8: 148-54. DOI: 10.17877/DE290R-8903
Anene, B.M., A. Ifebigh, I.A. Igwilo and P.U. Umeakuana. 2011. Prevalence and haemato-biochemical parameters of trypanosomes infected pigs at Nsukka, Nigeria. Comparative Clinical Pathology, 20(1): 15-18. DOI: 10.1007/s00580-009-0944-2
Anosa, V.O. 1988a. Haematological; and biochemical changes in human and animal trypanosomosis, Part I. Revue d’ Elevage et de Medecine Veterinaire des Pays Tropicaux, 4(1): 65-78.
Anosa, V.O. 1988b. Haematological; and biochemical changes in human and animal trypanosomosis, Part II. Revue d’ Elevage et de Medecine Veterinaire des Pays Tropicaux, 4(2): 151-164.
Awa, D.N. and C.N. Ndamkou. 2006. Response of Trypanosoma vivax and Trypanosoma congolense in zebu cattle in north Cameroon to prophylactic treatment with two formulations of isometamidium. Prev. Vet. Med., 76(1-2): 90-96. DOI: 10.1016/j.prevetmed.2006.04.011
Awobode, H.O. 2006. The biochemical changes induced by natural human African trypanosome infections. Afr. J. Biotechnol., 5(9): 738-742.
Baron, D.N., J.T. Whichen and K.E. Lee. 1989. A New Short Textbook of Chemical Pathology, 5th ed. (ELBS) Butler and Tanner Ltd., London Educational, Academic and Medical Publication Division of Hodder and Stoughton London, UK.
Coles, E.H. 1986. Veterinary Clinical Pathology, 4th ed. W.B.S. Saunder Co. Philadelphia, USA.
Dasilva, A.S., R.A. Zanette, P. Wolkmer, M.M. Costa, H.A. Garcia, S.T.A. Lopes, J.M. Santurio, M.M.G. Teixteria and S.G. Monteiro. 2009. Diminazene aceturate in the control of T. evansi infection in cats. Vet. Parasitol., 165(1-2): 47-50. DOI: 10.1016/j.vetpar.2009.06.025
Gill, B.S. 1991. Trypanosomes and Trypanosomiasis in Indian Livestock. Indian Council of Agricultural Research Publication, New Delhi, India.
Herbert, W.J. and M.D. Inglis. 1973. Immunization of mice, against T. brucei infection, by the administration of released antigen adsorbed to erythrocytes. Royal Society of Tropical Medicine and Hygiene, 67(2): 268. DOI: 10.1016/0035-9203(73)90174-0
Hilali, M., G.A. Abdel, A. Nassar and W.A. Abdel. 2006. Hematological and biochemical changes in water buffalo calves (B. bubalis) infected with T. evansi. Vet. Parasitol., 139(1-3): 237-243. DOI: 10.1016/j.vetpar.2006.02.013
Howes, F., A.S. Da Silva, C. de L. Athayde, M.M. Costa, M.M.B. Corrêa, K.C.S. Tavares, L.C. Miletti, S.T. dos A. Lopes, A.S. do Amaral and C. Schmidt. 2011. A new therapeutic protocol for dogs infected with T. evansi. Acta Sci. Vet., 39(3): 988. Available on: http://www.ufrgs.br/actavet/39-3/PUB%20988.pdf
Kadima, K.B., O.G. Erastus, I.S. Daniel and A.N.E. King. 2000. Serum biochemical values of T. vivax-infected cattle and the effects of lactose in saline infusion. Vet. Arhiv., 70(2): 67-74.
Keniko, J.J. 1997. Clinical Biochemistry of Domestic Animals, 5th ed. Academic Press, San Diego, USA.
Kennedy, G.E.P. 2004. Human African trypanosomiasis of the CNS: Current issues and challenges. J. Clin. Invest., 13(4): 496-504. DOI: 10.1172/JCI21052
Kulkarni, M.D., M.B. Nisal, R. Joshin and P.E. Kulkarni. 1997. Haemodynamic studies of trypanosomiasis in buffaloes (Bulalus bubalis). Indian Vet. J., 74(11): 981-982.
Kulkarni, M.D., M.B. Nisal, J.M.K. Rao and P.E. Kulkarni. 1996. Surra in cattle. Livestock Adviser, 21: 3-4.
Kumar, H., M.P. Gupta, P.K. Sidhu, V. Mahajan, M.S. Bal, K. Kaur, A.S. Verma and L.D. Singla. 2012. An outbreak of acute T. evansi infection in crossbred cattle in Punjab, India. Journal of Applied Animal Research, 40(3): 256-259. DOI: 10.1080/09712119.2012.667651
Kumar, R.M., N.M. Kamili, A. Saxena, A. Dan, S. Dey and S.S. Raut. 2011. Disturbance of oxidant/antioxidant equilibrium in horses naturally infected with T. evansi. Elsevier, Vet. Parasitol., 180(3-4): 349-353. DOI: 10.1016/j.vetpar.2011.03.029
Kumar, U., R. Jas and J.D. Ghosh. 2009. Effect of isometamidium hydrochloride on T. evansi infections in rats. Journal of Parasitic Diseases, 33(1-2): 36-41. DOI: 10.1007/s12639-009-0006-3
Lording, P.M. and S.C.E. Friend. 1991. Data analyasis guide. Interpretation of laboratory results. Aust. Vet. Pract., 21: 186-195.
Monzon, C.M., O.A. Mancebo and J.P. Roux. 1990. Comparison between six parasitological methods for diagnosis of T. evansi in the subtropical area of Argentina. Vet. Parasitol., 36(1-2): 141-146. DOI: 10.1016/0304-4017(90)90102-H
Moon, A.P., J.S. Williams and C. Witherspoon. 1968. Serum biochemical changes in mice infected with T. rhodesiense and T. duttoni. Experimental Parastology, 22(1): 112-121. DOI: 10.1016/0014-4894(68)90084-2
Omejea, J.N. and B.M. Aneneb. 2012. Comparative serum biochemical changes induced by experimental infection of T. brucei and T. congolense in pigs. Vet. Parasitol., 190(2-4): 368-374. DOI: 10.1016/j.vetpar.2012.07.008
Pathak, K.M.L. and N. Singh. 2005. Animal trypanosomiasis. Intas Polivet, 6(11): 194-199.
Pholpark, S., M. Pholpark, S. Sarataphan, S. Khunpasi and P. Taboran. 1984. T. evansi infection in buffalo in northeast Thailand. In Proceedings of the 11th Annual Conference of the Thailand Veterinary Medical Association, Bangkok, Thailand.
Taiwo, V.O., M.O. Olaniyi and A.O. Ogunsanmi. 2003. Comparative plasma biochemical changes and susceptibility of erythrocytes to in vitro peroxidation during experimental T. congolense and T. brucei infections in sheep. Isr. J. Vet. Med., 58(4): 30-33.
Takeet, M. and B.O. Fagbemi. 2009. Haematological, pathological and plasma biochemical changes in rabbits experimentally infected with T. congolense. Science World Journal, 4(2): 29-36. DOI: 10.4314/swj.v4i2.51843
Toro, M., E. León, R. López, F. Pallota and A. Ruiz. 1983. Effect of isometamidium on infections by T. vivax and T. Evansi in experimentally infected animals. Vet. Parasitol., 13(1): 35-43. DOI: 10.1016/0304-4017(83)90018-3
Ugochukwu, E.I. 1986. Haematological observations on bovine trypanosomiasis of Holstein-Friesian breed. Int. J. Zoonoses, 13(2): 89-92.
Walia, P.S., I.S. Kalra, P.D. Juyal and S.P. Ahuja. 1996. Role of activity of Trypanosoma evansi in inducing anemia and immunomodulation in buffalo calves. J. Vet. Parasitol., 10(1): 1-9.
Wellde, B.T., R. Lotzsch, G. Diehl, E. Sadun, J. Williams and G. Warui. 1974. Trypanosoma congolense: I. clinical observations of experimentally infected cattle. Exp. Parasitol., 36(1): 6-19. DOI: 10.1016/0014-4894(74)90107-6
Wilkinson, J.H. 1962. An Introduction to Diagnostic Enzymology. Edward Arnold (Publishers) Ltd., London, UK. p. 1-277.
Abenga, J.N. and V.O. Anosa. 2005. Serum total proteins and creatinine levels in experimental Gambian trypanosomosis of vervet monkeys. Afr. J. Biotech, 4(2): 187-190. Available on: https://tspace.library.utoronto.ca/bitstream/1807/6612/1/jb05035.pdf
Ajayi, O.O., E.L. Toshak, O.B. Obaloto, B. Iliyasu, A.C. Igweh, A.J. Dadah and C.O. Idehen. 2013. Comparative efficacy of Berenil and Samorin in albino rats experimentally infected with current field isolates of T. brucei brucei. International Journal of Biological and Chemical Sciences, 7(4): 1452-1460. DOI: 10.4314/ijbcs.v7i4.3
Akanji, M.A., O.S. Adeyemi, S.O. Oguntoye and F. Sulyman. 2009. Psidium guajava extract reduces trypanosomosis associated lipid peroxidation and raises glutathione concentrations in infected animals. EXCLI J., 8: 148-54. DOI: 10.17877/DE290R-8903
Anene, B.M., A. Ifebigh, I.A. Igwilo and P.U. Umeakuana. 2011. Prevalence and haemato-biochemical parameters of trypanosomes infected pigs at Nsukka, Nigeria. Comparative Clinical Pathology, 20(1): 15-18. DOI: 10.1007/s00580-009-0944-2
Anosa, V.O. 1988a. Haematological; and biochemical changes in human and animal trypanosomosis, Part I. Revue d’ Elevage et de Medecine Veterinaire des Pays Tropicaux, 4(1): 65-78.
Anosa, V.O. 1988b. Haematological; and biochemical changes in human and animal trypanosomosis, Part II. Revue d’ Elevage et de Medecine Veterinaire des Pays Tropicaux, 4(2): 151-164.
Awa, D.N. and C.N. Ndamkou. 2006. Response of Trypanosoma vivax and Trypanosoma congolense in zebu cattle in north Cameroon to prophylactic treatment with two formulations of isometamidium. Prev. Vet. Med., 76(1-2): 90-96. DOI: 10.1016/j.prevetmed.2006.04.011
Awobode, H.O. 2006. The biochemical changes induced by natural human African trypanosome infections. Afr. J. Biotechnol., 5(9): 738-742.
Baron, D.N., J.T. Whichen and K.E. Lee. 1989. A New Short Textbook of Chemical Pathology, 5th ed. (ELBS) Butler and Tanner Ltd., London Educational, Academic and Medical Publication Division of Hodder and Stoughton London, UK.
Coles, E.H. 1986. Veterinary Clinical Pathology, 4th ed. W.B.S. Saunder Co. Philadelphia, USA.
Dasilva, A.S., R.A. Zanette, P. Wolkmer, M.M. Costa, H.A. Garcia, S.T.A. Lopes, J.M. Santurio, M.M.G. Teixteria and S.G. Monteiro. 2009. Diminazene aceturate in the control of T. evansi infection in cats. Vet. Parasitol., 165(1-2): 47-50. DOI: 10.1016/j.vetpar.2009.06.025
Gill, B.S. 1991. Trypanosomes and Trypanosomiasis in Indian Livestock. Indian Council of Agricultural Research Publication, New Delhi, India.
Herbert, W.J. and M.D. Inglis. 1973. Immunization of mice, against T. brucei infection, by the administration of released antigen adsorbed to erythrocytes. Royal Society of Tropical Medicine and Hygiene, 67(2): 268. DOI: 10.1016/0035-9203(73)90174-0
Hilali, M., G.A. Abdel, A. Nassar and W.A. Abdel. 2006. Hematological and biochemical changes in water buffalo calves (B. bubalis) infected with T. evansi. Vet. Parasitol., 139(1-3): 237-243. DOI: 10.1016/j.vetpar.2006.02.013
Howes, F., A.S. Da Silva, C. de L. Athayde, M.M. Costa, M.M.B. Corrêa, K.C.S. Tavares, L.C. Miletti, S.T. dos A. Lopes, A.S. do Amaral and C. Schmidt. 2011. A new therapeutic protocol for dogs infected with T. evansi. Acta Sci. Vet., 39(3): 988. Available on: http://www.ufrgs.br/actavet/39-3/PUB%20988.pdf
Kadima, K.B., O.G. Erastus, I.S. Daniel and A.N.E. King. 2000. Serum biochemical values of T. vivax-infected cattle and the effects of lactose in saline infusion. Vet. Arhiv., 70(2): 67-74.
Keniko, J.J. 1997. Clinical Biochemistry of Domestic Animals, 5th ed. Academic Press, San Diego, USA.
Kennedy, G.E.P. 2004. Human African trypanosomiasis of the CNS: Current issues and challenges. J. Clin. Invest., 13(4): 496-504. DOI: 10.1172/JCI21052
Kulkarni, M.D., M.B. Nisal, R. Joshin and P.E. Kulkarni. 1997. Haemodynamic studies of trypanosomiasis in buffaloes (Bulalus bubalis). Indian Vet. J., 74(11): 981-982.
Kulkarni, M.D., M.B. Nisal, J.M.K. Rao and P.E. Kulkarni. 1996. Surra in cattle. Livestock Adviser, 21: 3-4.
Kumar, H., M.P. Gupta, P.K. Sidhu, V. Mahajan, M.S. Bal, K. Kaur, A.S. Verma and L.D. Singla. 2012. An outbreak of acute T. evansi infection in crossbred cattle in Punjab, India. Journal of Applied Animal Research, 40(3): 256-259. DOI: 10.1080/09712119.2012.667651
Kumar, R.M., N.M. Kamili, A. Saxena, A. Dan, S. Dey and S.S. Raut. 2011. Disturbance of oxidant/antioxidant equilibrium in horses naturally infected with T. evansi. Elsevier, Vet. Parasitol., 180(3-4): 349-353. DOI: 10.1016/j.vetpar.2011.03.029
Kumar, U., R. Jas and J.D. Ghosh. 2009. Effect of isometamidium hydrochloride on T. evansi infections in rats. Journal of Parasitic Diseases, 33(1-2): 36-41. DOI: 10.1007/s12639-009-0006-3
Lording, P.M. and S.C.E. Friend. 1991. Data analyasis guide. Interpretation of laboratory results. Aust. Vet. Pract., 21: 186-195.
Monzon, C.M., O.A. Mancebo and J.P. Roux. 1990. Comparison between six parasitological methods for diagnosis of T. evansi in the subtropical area of Argentina. Vet. Parasitol., 36(1-2): 141-146. DOI: 10.1016/0304-4017(90)90102-H
Moon, A.P., J.S. Williams and C. Witherspoon. 1968. Serum biochemical changes in mice infected with T. rhodesiense and T. duttoni. Experimental Parastology, 22(1): 112-121. DOI: 10.1016/0014-4894(68)90084-2
Omejea, J.N. and B.M. Aneneb. 2012. Comparative serum biochemical changes induced by experimental infection of T. brucei and T. congolense in pigs. Vet. Parasitol., 190(2-4): 368-374. DOI: 10.1016/j.vetpar.2012.07.008
Pathak, K.M.L. and N. Singh. 2005. Animal trypanosomiasis. Intas Polivet, 6(11): 194-199.
Pholpark, S., M. Pholpark, S. Sarataphan, S. Khunpasi and P. Taboran. 1984. T. evansi infection in buffalo in northeast Thailand. In Proceedings of the 11th Annual Conference of the Thailand Veterinary Medical Association, Bangkok, Thailand.
Taiwo, V.O., M.O. Olaniyi and A.O. Ogunsanmi. 2003. Comparative plasma biochemical changes and susceptibility of erythrocytes to in vitro peroxidation during experimental T. congolense and T. brucei infections in sheep. Isr. J. Vet. Med., 58(4): 30-33.
Takeet, M. and B.O. Fagbemi. 2009. Haematological, pathological and plasma biochemical changes in rabbits experimentally infected with T. congolense. Science World Journal, 4(2): 29-36. DOI: 10.4314/swj.v4i2.51843
Toro, M., E. León, R. López, F. Pallota and A. Ruiz. 1983. Effect of isometamidium on infections by T. vivax and T. Evansi in experimentally infected animals. Vet. Parasitol., 13(1): 35-43. DOI: 10.1016/0304-4017(83)90018-3
Ugochukwu, E.I. 1986. Haematological observations on bovine trypanosomiasis of Holstein-Friesian breed. Int. J. Zoonoses, 13(2): 89-92.
Walia, P.S., I.S. Kalra, P.D. Juyal and S.P. Ahuja. 1996. Role of activity of Trypanosoma evansi in inducing anemia and immunomodulation in buffalo calves. J. Vet. Parasitol., 10(1): 1-9.
Wellde, B.T., R. Lotzsch, G. Diehl, E. Sadun, J. Williams and G. Warui. 1974. Trypanosoma congolense: I. clinical observations of experimentally infected cattle. Exp. Parasitol., 36(1): 6-19. DOI: 10.1016/0014-4894(74)90107-6
Wilkinson, J.H. 1962. An Introduction to Diagnostic Enzymology. Edward Arnold (Publishers) Ltd., London, UK. p. 1-277.
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Published
2021-03-26
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Singh, A. P., Tripathi, A. K., Pandey, R. P., & Srivastava, A. (2021). Therpeutic efficacy evaluation of commonly used antitrypanosomal drugs in naturally infected buffaloes. Buffalo Bulletin, 40(1), 19–30. Retrieved from https://kuojs.lib.ku.ac.th/index.php/BufBu/article/view/823
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