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The study was conducted on 18 clinical cases of ketosis presented in the Teaching Veterinary Clinical Complex, Faculty of Veterinary Science and Animal Husbandry (F.V.Sc & A.H), R.S. Pura and areas around R.S. Pura Tehsil. Clinical and haemato-biochemical parameters were studied in the affected animals. A minor decrease in mean body temperature with an increase in severity of ketosis was noted. The severe cases had diminished rate of ruminal motility and prominent clinical signs were sudden and unexpected drop in milk production, depraved appetite, wasting and depression. Biochemical parameters viz. plasma glucose, total plasma protein, LDL and HDL-cholesterol, calcium and magnesium decreased significantly.