Metabolites from microbial co-cultures and their functional properties
Main Article Content
Abstract
Co-culture involves growing multiple strains of microorganisms together in the same environment to improve production efficiency. This method utilizes the complementary strengths of different microorganisms, producing various metabolites during fermentation. These metabolites, including primary and secondary metabolites, are affected by factors such as the types of microorganisms and the fermentation environment. Co-fermentation results in diverse metabolites, including those produced from the co-fermentation of different yeast strains, yeast and bacteria, and yeast and algae. These processes involve metabolic pathways that complement each other, resulting in metabolites with distinct functional properties. These metabolites not only increase nutritional value and improve taste and smell but also extend the final product's shelf life and enhance production efficiency. The microbial co-fermentation process is powerful for producing valuable metabolites with applications across industries such as health food and pharmaceuticals. The use of microbial co-cultures has shown significant potential in improving bioproduct efficiency. By taking advantage of the synergistic interactions between different microorganisms, co-cultures offer a wide range of functional properties, including enhanced metabolic pathways and the production of unique metabolites with valuable industrial applications. Therefore, metabolites from microbial co-cultures represent a promising strategy for optimizing bioproduction processes and advancing bioproduct development.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
Singh R, Kumar M, Mittal A, Mehta PK. Microbial metabolites in nutrition, healthcare and agriculture. 3Biotech. 2017;7(1):15.
Son EY, Lee SM, Kim M, Seo J-A, Kim Y-S. Comparison of volatile and non-volatile metabolites in rice wine fermented by Koji inoculated with Saccharomycopsis fibuligera and Aspergillus oryzae. Food Res Int. 2018;109:596-605.
Schulz-Bohm K, Martín-Sánchez L, Garbeva P. Microbial volatiles: small molecules with an important role in intra- and inter-kingdom interactions. Front Microbiol. 2017;8:2484.
Duarte WF, Amorim JC, Schwan RF. The effects of co-culturing non-Saccharomyces yeasts with S. cerevisiae on the sugar cane spirit (cachaça) fermentation process. Antonie van Leeuwenhoek. 2013;103(1):175-94.
Hashem M, Alamri SA, Asseri TAY, Mostafa YS, Lyberatos G, Ntaikou I. On the optimization of fermentation conditions for enhanced bioethanol yields from starchy biowaste via yeast co-cultures. Sustainability. 2021;13(4):1890.
Chen Y. Development and application of co-culture for ethanol production by co-fermentation of glucose and xylose: a systematic review. J Ind Microbiol Biotechnol. 2011;38(5):581-97.
Nenciarini S, Reis-Costa A, Pallecchi M, Renzi S, D’Alessandro A, Gori A, et al. Investigating yeast–Lactobacilli interactions through co-culture growth and metabolite analysis. Fermentation. 2023;9(11):933.
Chan MZA, Tan LT, Heng SWQ, Liu SQ. Effect of co-fermentation of Saccharomyces boulardii CNCM-I745 with four different probiotic Lactobacilli in coffee brews on cell viabilities and metabolic activities. Fermentation. 2023;9(3):219.
Boudaoud S, Aouf C, Devillers H, Sicard D, Segond D. Sourdough yeast-bacteria interactions can change ferulic acid metabolism during fermentation. Food Microbiol. 2021;98:103790.
Kadyan S, Rashmi HM, Pradhan D, Kumari A, Chaudhari A, Deshwal GK. Effect of lactic acid bacteria and yeast fermentation on antimicrobial, antioxidative and metabolomic profile of naturally carbonated probiotic whey drink. LWT. 2021;142:111059.
Senne de Oliveira Lino F, Bajic D, Vila JCC, Sánchez A, Sommer MOA. Complex yeast–bacteria interactions affect the yield of industrial ethanol fermentation. Nature Communications. 2021;12(1):1498.
Xu Z, Theodoropoulos C, Pittman JK. Optimization of a Chlorella–Saccharomyces co–culture system for enhanced metabolite productivity. Algal Res. 2024;79:103455.
Khammee P, Ramaraj R, Whangchai N, Bhuyar P, Unpaprom Y. The immobilization of yeast for fermentation of macroalgae Rhizoclonium sp. for efficient conversion into bioethanol. Biomass Conversion and Biorefinery. 2021;11(3):827-35.
Dillschneider R, Schulze I, Neumann A, Posten C, Syldatk C. Combination of algae and yeast fermentation for an integrated process to produce single cell oils. Appl Microbiol Biotechnol. 2014;98(18):7793-802.
He W, Tian Y, Liu S, Vaateri L, Ma X, Haikonen T, et al. Comparison of phenolic composition and sensory quality among pear beverages made using Saccharomyces cerevisiae and Torulaspora delbrueckii. Food Chem. 2023;422:136184.
Han X, Qin Q, Li C, Zhao X, Song F, An M, et al. Application of non-Saccharomyces yeasts with high β-glucosidase activity to enhance terpene-related floral flavor in craft beer. Food Chem. 2023;404:134726.
Fan T, Qu J, Wang L, Zhang J, Yang X, Zhang H, et al. Genome sequencing, assembly, and characterization of Pichia fermentans Z9Y-3 as a non-Saccharomyces yeast with aroma enhancing potential. Food Biosci. 2023;53:102701.
Pirrone A, Prestianni R, Naselli V, Todaro A, Farina V, Tinebra I, et al. Influence of indigenous Hanseniaspora uvarum and Saccharomyces cerevisiae from sugar-rich substrates on the aromatic composition of loquat beer. Int J Food Microbiol. 2022;379:109868.
Rai AK, Pandey A, Sahoo D. Biotechnological potential of yeasts in functional food industry. Trends Food Sci Technol. 2019;83:129-37.
Chaves-López C, Serio A, Paparella A, Martuscelli M, Corsetti A, Tofalo R, et al. Impact of microbial cultures on proteolysis and release of bioactive peptides in fermented milk. Food Microbiol. 2014;42:117-21.
Rekha CR, Vijayalakshmi G. Biomolecules and nutritional quality of soymilk fermented with probiotic yeast and bacteria. Appl Microbiol Biotechnol. 2008;151(2):452-63.
Chandrasekar Rajendran SC, Chamlagain B, Kariluoto S, Piironen V, Saris PEJ. Biofortification of riboflavin and folate in idli batter, based on fermented cereal and pulse, by Lactococcus lactis N8 and Saccharomyces boulardii SAA655. J Appl Microbiol. 2017;122(6):1663-71.
Nakamura Y, Yamamoto N, Sakai K, Takano T. Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to Angiotensin I-Converting Enzyme. J Dairy Sci. 1995;78(6):1253-7.
Xie X, zheng M, Bai Y, Zhang Z, Zhang M, Chen Z, et al. Effect of Lactiplantibacillus plantarum and Saccharomyces cerevisiae fermentation on the multi-scale structure and physicochemical properties of highland barley starch. Food Biosci. 2023;52:102419.
Malbaša RV, Lončar ES, Vitas JS, Čanadanović-Brunet JM. Influence of starter cultures on the antioxidant activity of kombucha beverage. Food Chem. 2011;127(4):1727-31.
Carbonetto B, Nidelet T, Guezenec S, Perez M, Segond D, Sicard D. Interactions between Kazachstania humilis yeast species and lactic acid bacteria in Sourdough. Microorganisms. 2020;8(2).